Conférence 9 avril 2026

Dr Gaëlle Blond (Université de Strasbourg)

Development of Gold-Mediated One-Pot Reactions :An Access to O, N,and S-Heterocycles

Heterocycles represent structural architectures frequently found in biologically active natural and unnatural compounds, drugs, and agrochemicals. Significant advances toward the synthesis of heterocyclic compounds have been achieved in homogeneous gold catalysis. Besides, over the past decade, homogeneous gold catalysis as part of one-pot processes has been the subject of intense research because of its potential to rapidly build molecular complexity. Prompted by the above considerations, we have developed versatile methodologies leading to O, N and S-heterocycles such as furopyrans, benzothiophenes, benzoazepines, furooxepines, thiazepanes, and fonctionalized lactones in a highly efficient and straightforward manner through gold-mediated one-pot reactions.[1-6]

References

1. Gold(I)-Catalyzed Synthesis of Furopyrans: Insight into Hetero-Diels−Alder Reactions. R. Pertschi, P. Wagner, N. Ghosh, V. Gandon, G. Blond Org. Lett., 2019, 21, 6084.

2. Solvent Effect in Gold(I)-Catalyzed Domino Reaction : Access to Furopyrans. P. Wagner, N. Ghosh, V. Gandon, G. Blond Org. Lett., 2020, 22, 7333

3. Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis. M. Ruch, N. Brach, R. Galéa, P. Wagner, G. Blond Molecules, 2020, 25, 4976

4. Gold(I)-Catalyzed Carbothiolation via Rearrangement of S-Propargyl Group: An Access to 3-Allenyl or 3-Indenyl Benzo[b]thiophenes. C. Van Wesemael, N. Brach, M. Gulea, G. Blond Adv. Synth. Catal., 2022, 364, 4141

5. Gold(I)-Catalyzed Domino Reaction : An Access to furooxepines. Galéa, G. Blond, Adv. Synth. Catal., 2022, 364, 1532

6. Access to 1,4-Thiazepanes via Gold-Catalyzed 7-exo-dig Thioallylation and their Cycloisomerization to Bicyclic [4.3.1] Bridgehead-Olefinic Systems. Choury, P. Wagner, C. Rognan, G. Blond, M. Gulea Adv. Synth. Catal., 2022, 364, 3238

7. Orthogonal Tandem Catalysis involving Au(I)-Hydroacyloxylation and Rh(I)-Hydroformylation reactions E. Salvi, R. Galéa, C. Van Wesemael, P. Wagner, N. Girard, G. Blond Org. Chem. Front. 2025, 12, 3050

8. Synthesis of S- and N,S-heterocycles by gold-catalyzed cyclizations C. Van Wesemael, M. Choury, P. Wagner, C. Rognan, G. Blond, M. Gulea Phosphorus, Sulfur, and Silicon and the Related Elements 2025, 10.1080/10426507.2025.2522705