Conférence du Dr Morgan Donnard – Captodative Aminoalkenes: Great Precursors to Access Original Heterocycle

Morgan Donnard, CR-CNRS au Laboratoire d’Innovation Moléculaire et Applications (LIMA, Université de Strasbourg) donnera le 16 Novembre 2023 à 14h30 dans la salle Jean Barriol de la FST-UL une conférence intitulée « Captodative Aminoalkenes : Great Precursors to Access Original Heterocycles »

Abstract : Captodative enamides are particularly functionalized building blocks, opening up a wide range of applications in synthetic chemistry, particularly in heterocyclic synthesis. However, access to these compounds remains particularly limited, especially in the case of tetrasubstituted C=C double bonds, due to regio- and stereoselectivity problems. In this lecture, we present the selective and efficient synthetic routes to captodative enamides that we have developed. These syntheses are based on ynamide difunctionalizations, and we will then present our first applications of these building blocks to obtain totally original heterocycles, including unprecedented silacyclic fluorophores.